Arrhythmias & electrophysiology
Adverse Prognosis of Patients With Septal Substrate After Ventricular Tachycardia (VT) Ablation Due to Electrical Storm
Main finding · CV mortalityResult — go to the resultHazard ratio 4.192 CI 1.194–14.719Authors' conclusion
Presence of a septal substrate is associated with adverse long-term cardiovascular mortality in patients admitted for VT ablation after ES. Despite decreased acute ablation successes in these patients, VT recurrence rates were similar to those without a septal substrate during follow-up.
Study context
- Population
- Patients undergoing first VT ablation for electrical storm, June 2018 to April 2021
- Participants
- 107 patients
- Exposure
- Septal substrate vs no septal substrate
- Outcome
- CV mortality
- Follow-up
- Median 22 months
Methodological detailssingle-centre, consecutive patients
- Single-centre
- Consecutive patients
Main finding
As reported in the abstract
Hazard ratio
4.192
CI 1.194–14.719
P = 0.025
By group
Observational data: associations, not effects.
Further findings
Partial ablation success · similar
P = 0.251
Complete ablation success
P = 0.004
Independent predictors of adverse outcome (multivariable regression)
- Septal substrate, HR
- 5.723; P = 0.025
- Increased age, HR
- 1.104; P = 0.003
Recurrence of any ventricular arrhythmia
- Similar between groups (67% vs 56%)
- log rank P = 0.554
Rehospitalization
- Similar between groups (80% vs 66%)
- log rank P = 0.515
Recurrence of clinical VT
- Similar (7% vs 2%)
- P = 0.252
Safety
Postinterventional third-degree AV block
P = 0.063
Major complications (all patients)
- Major complications, all patients
- 11%
Original publication
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