Arrhythmias & electrophysiology
Pulsed-Field Ablation Does Not Worsen Baseline Pulmonary Hypertension Following Prior Radiofrequency Ablations
Authors' conclusion
In this propensity-matched population, no worsening of mPAP was detected following pulsed-field ablation in patients with pre-existing PH undergoing a repeat procedure for recurrence.
Study context
- Population
- Non-paroxysmal AF patients with pulmonary hypertension (PH) (resting mean pulmonary artery pressure (PAP) >20 mm Hg) undergoing repeat ablation
- Participants
- 28 vs 28
- Exposure
- Pulsed-field ablation (PFA) vs repeat radiofrequency ablation (RFA)
- PFAn = 28
- RFAn = 28reference
- Outcome
- Change in mPAP from baseline (adjusted for baseline mPAP, ANCOVA)
- Follow-up
- 3 months after ablation
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Least-squares mean change in mPAP
PFA
−1.71
least-squares mean change · ± 1.03 · mm Hg
RFA
19.67
least-squares mean change · ± 1.03 · mm Hg
P < 0.001
Observational data: associations, not effects.
Further findings
- Comparable baseline mean pulmonary artery pressures (mPAP) between groups
- P = 0.177
Original publication
Pulsed-Field Ablation Does Not Worsen Baseline Pulmonary Hypertension Following Prior Radiofrequency Ablations. JACC Clin Electrophysiol. Published 22 November 2023. doi:10.
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