Arrhythmias & electrophysiology
Severity of Ischemic Stroke After Left Atrial Appendage Closure vs Nonwarfarin Oral Anticoagulants
Authors' conclusion
Ischemic strokes in patients with atrial fibrillation are less often disabling or fatal with LAAC than DOAC prophylaxis.
Study context
- Population
- AF patients with ischemic stroke (IS) during left atrial appendage closure (LAAC) or direct oral anticoagulant (DOAC) prophylaxis
- Participants
- 125 vs 322
- Exposure
- LAAC vs DOAC prophylaxis
- ISLAACn = 125
- ISDOACn = 322reference
- Outcome
- Disabling/fatal stroke (modified Rankin Scale 3-5)
- Follow-up
- Discharge and 3 months later
Methodological detailsmulticentre (8 centres), consecutive patients, propensity score matching, multivariate regression
- Multicentre (8 centres)
- Consecutive patients
- Propensity score matching
- Multivariate regression
Main finding
As reported in the abstract
Disabling/fatal stroke (mRS 3-5) · discharge and 3 months
ISLAAC
- Discharge
- 38.3%
- 3 months
- 33.3%
ISDOAC
- Discharge
- 70.3%
- 3 months
- 56.2%
Discharge
ISLAAC38.3%
ISDOAC70.3%
3 months
ISLAAC33.3%
ISDOAC56.2%
ISLAAC vs ISDOACOdds ratio (95% CI)P value
Discharge; multivariate regression
0.22(0.13–0.39)
P < 0.0013 months; multivariate regression
0.25(0.12–0.50)
P < 0.001Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Death · 3 monthsMultivariate regression | 0.28 (0.12–0.64) | P < 0.001 | |
| 0.10.31310Odds ratio (log scale) |
Original publication
Severity of Ischemic Stroke After Left Atrial Appendage Closure vs Nonwarfarin Oral Anticoagulants. JACC Clin Electrophysiol. Published 22 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →