Arrhythmias & electrophysiology

Pulsed-Field Ablation on Mitral Isthmus in Persistent Atrial Fibrillation: Preliminary Data on Efficacy and Safety

JACC Clin ElectrophysiolPublished Prospective cohort study

Authors' conclusion

PFA is a feasible and safe ablation approach for mitral isthmus ablation in addition to PVI in patients with persistent AF.

Study context

Population
Consecutive patients with persistent atrial fibrillation (AF) undergoing a first ablation procedure with pulsed-field ablation (PFA), November 2021 to September 2022
Participants
45 patients
Outcome
Persistent mitral isthmus block at end of procedure (feasibility)
Follow-up
End of the procedure
Methodological detailsconsecutive patients, single-group
  • Consecutive patients
  • Single-group

Main finding

As reported in the abstract

Complete mitral isthmus block

PFA

100%

45 of 45

Observational data: associations, not effects.

Further findings

Recurrence · mean follow-up 107.8 ± 59.5 days

Recurrence rate
20%

Safety

Complications

Patients with complications
3

Reversible, nonfatal coronary spasm

Coronary spasm cases
2 (4.4%)

Original publication

Pulsed-Field Ablation on Mitral Isthmus in Persistent Atrial Fibrillation: Preliminary Data on Efficacy and Safety. JACC Clin Electrophysiol. Published 21 June 2023. doi:10.1016/j.jacep.2023.03.021

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