Arrhythmias & electrophysiology
Pulsed Field Ablation–Related Hemolysis: Comparison Between Technologies
Authors' conclusion
PFA-induced hemolysis is common, with different PFA technologies exhibiting variable degrees of hemolysis, lower with the focal PFA catheter Sphere-9 when compared with single-shot PFA catheters.
Study context
- Population
- Pulsed field ablation (PFA) procedures for AF with haptoglobin measured at baseline and postoperative day 1
- Participants
- 552 PFA procedures
- Exposure
- Farawave vs Sphere-9 vs Pulseselect vs Varipulse PFA catheters
- Outcome
- Hemolysis (reduction in Hp >10 mg/dL)
- Follow-up
- Postoperative day 1
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Hemolysis (Hp reduction >10 mg/dL)
- Hemolysis overall
- 95%
Observational data: associations, not effects.
Further findings
Significant (Hp-POD1 ≤25 mg/mL) and severe (Hp-POD1 ≤10 mg/mL) hemolysis · postoperative day 1
Significant
Severe
| Outcome | Farawave | Sphere-9 | Pulseselect | Varipulse |
|---|---|---|---|---|
| Hp reduction from baseline · postoperative day 1Mean, mg/dL | 94 (SD 40) | 39 (SD 23) | 62 (SD 25) | 85 (SD 32) |
| Hp decrease per PFA application (linear relationship) | 0.47 (95% CI 0.22–0.71) mg/dL | 0.10 (95% CI 0.02–0.19) mg/dL | 0.40 (95% CI 0.09–0.73) mg/dL | — not stated in the abstract |
— not stated in the abstract
- Significant (Hp-POD1 ≤25 mg/mL) and severe (Hp-POD1 ≤10 mg/mL) hemolysis — Significant hemolysis overall
- 34%
- Significant (Hp-POD1 ≤25 mg/mL) and severe (Hp-POD1 ≤10 mg/mL) hemolysis — Severe hemolysis overall
- 13%
- Hp reduction from baseline — Mean Hp decrease overall (±SD)
- 76±40 mg/dL
Hp reduction from baseline · postoperative day 1
- Significantly greater reduction with Farawave and Varipulse vs Pulseselect or Sphere-9
Original publication
Pulsed Field Ablation–Related Hemolysis: Comparison Between Technologies. Circ Arrhythm Electrophysiol. Published 2 December 2025. doi:10.
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