Quality of Life After Transcatheter Aortic Valve Replacement in Normal-Flow, Low-Gradient Aortic Stenosis

Khaleel, I; Harris, AW; Seth, M; Sukul, D; Deeb, GM; Joseph, MS; Grossman, PM; Fukuhara, S; Chetcuti, S

doi:10.1016/j.jacadv.2023.100641

Valvular & structural heart disease

Quality of Life After Transcatheter Aortic Valve Replacement in Normal-Flow, Low-Gradient Aortic Stenosis

JACC AdvPublished 5 Oct 2023Cohort study

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Authors' conclusion

Selected patients with NF-LG AS experienced similar improvement in QoL after TAVR compared with HG-AS.

Study context

Population: Patients who underwent transcatheter AVR (TAVR) for severe aortic stenosis (AS), divided into 4 hemodynamic profiles
Participants: 860 patients

Exposure: NF-LG AS vs high-gradient aortic stenosis (HG-AS) after TAVR
NF-LG ASn = 245
HG-ASn = 368reference
Outcome: Composite clinical improvement:
Survival to 1 year and improved KCCQ overall summary score of ≥5 points
Adjusted for baseline factors
Follow-up: 1 year

Main finding

Clinical improvement (composite)

Adjusted odds ratio

0.72

95% CI 0.47–1.11

By group

HG-AS70.4%

NF-LG AS63.9%

As reported in the abstract

Observational data: associations, not effects.

Further findings

1-year Kaplan-Meier mortality

P < 0.001

HG-AS5.8%

NF-LG AS12.9%

Original publication

Quality of Life After Transcatheter Aortic Valve Replacement in Normal-Flow, Low-Gradient Aortic Stenosis. JACC Adv. Published 5 October 2023. doi:10.1016/j.jacadv.2023.100641

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