Coronary disease & ACS

Quantitative coronary CT analysis reveals non-calcified atherosclerotic plaques in women with a history of pre-eclampsia

Eur J Prev CardiolPublished Cross-sectional study

Main finding · Noncalcified plaque volume (among women with plaques)Result — go to the resultbeta 0.62 95% CI 0.17–1.07

Authors' conclusion

Women with a history of preeclampsia have coronary plaques with larger noncalcified plaque volume compared to unaffected women, driven by larger fibrous and fibrous fatty plaque volumes, independent of total plaque volume.

Study context

Population
Women aged 45–55 years undergoing coronary CT angiography
Participants
138 vs 390
Exposure
History of pre-eclampsia vs no history of pre-eclampsia
  • Preeclampsian = 138
  • Referencen = 390reference
Outcome
Coronary plaque characteristics: total, calcified and noncalcified plaque volumes (quantitative coronary computed tomography angiography (CCTA))

Main finding

As reported in the abstract

Noncalcified plaque volume (among women with plaques)

beta

0.62

95% CI 0.17–1.07

Observational data: associations, not effects.

Further findings

OutcomeBeta (95% CI)
Fibrous and fibrous fatty plaque volume (among women with plaques)Preeclampsia vs Reference · fibrous plaque0.71 (0.26–1.15)
Fibrous and fibrous fatty plaque volume (among women with plaques)Preeclampsia vs Reference · fibrous fatty plaque0.52 (0.01–1.03)

Original publication

Quantitative coronary CT analysis reveals non-calcified atherosclerotic plaques in women with a history of pre-eclampsia. Eur J Prev Cardiol. Published 18 November 2025. doi:10.1093/eurjpc/zwaf713

Summarised from the published abstract; every number is checked against it

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