Coronary disease & ACSCohort study
15-Year Cardiovascular Risk in Patients With Angina Without Obstructive Coronary Arteries
- Matched cohort study
- 1:5 age- and sex-matched
- age- and sex-stratified analyses
- Median follow-up 10.7 years (maximum 15)
Authors' conclusion
Patients with ANOCA have a similar risk for myocardial infarction, lower mortality, and a marginally higher risk for ischemic stroke than the general population. Results were age and sex dependent.
Study context
- Population
- Patients with suspected stable angina referred for coronary angiography 2003–2021 with no or mild CAD1:5 matched
- Participants
- 21,132 vs 105,660
- Exposure
- ANOCA vs matched general population
- ANOCAn = 21,132
- General populationn = 105,660reference
- Outcome
- MI, ischemic stroke and death
- Follow-up
- 15 years
Main finding
As reported in the abstract
ANOCA
3.5%
MI · Ischemic stroke 3.7% · Mortality 25.4%
General population
3.5%
MI · Ischemic stroke 2.9% · Mortality 26.4%
ANOCA vs General populationRisk difference (95% CI)
MI
0.0%(−0.3% to 0.4%)
ischemic stroke
0.8%(0.5%–1.2%)
mortality
−0.9%(−1.8% to −0.1%)
Observational data: associations, not effects.
Further findings
Risk by sex and age (subgroups)
- Men and older (≥75 years) patients had the lowest risks vs matched general population
Original publication
15-Year Cardiovascular Risk in Patients With Angina Without Obstructive Coronary Arteries. JACC Cardiovasc Interv. Published 14 November 2025. doi:10.1016/j.jcin.2025.09.014
Summarised from the published abstract; every number is checked against it