Valvular & structural heart disease
Quantitative Fluid Overload in Severe Aortic Stenosis Refines Cardiac Damage and Associates with Worse Outcomes
Main finding · HHF and/or deathResult — go to the resultAdjusted hazard ratio 1.13 95% CI 1.06–1.22Authors' conclusion
Quantitative FO in patients with severe AS improves risk prediction of worse post-interventional outcomes compared to traditional risk assessment.
Study context
- Population
- Patients with severe aortic stenosis (AS) scheduled for transcatheter aortic valve implantation (TAVI)360 (41%) with fluid overload (FO)
- Participants
- 880 patients
- Exposure
- FO vs no FO, stratified by right-sided cardiac damage
- Outcome
- Hospitalization for HF and/or death
- Follow-up
- 2.4 ± 1.0 years
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
HHF and/or death
Adjusted hazard ratio
1.13
95% CI 1.06–1.22
P < 0.001
Every 1.0 L increase in bioimpedance
adjusted HR 1.13 (95% CI 1.06–1.22); P < 0.001
Every 1.0 L increase in bioimpedance, as printed
As reported in the abstract
Observational data: associations, not effects.
Further findings
Clinical congestion signs in patients with FO
- Clinical examination unremarkable for congestion signs
- >50%
Original publication
Quantitative Fluid Overload in Severe Aortic Stenosis Refines Cardiac Damage and Associates with Worse Outcomes. Eur J Heart Fail. Published 26 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →