Valvular & structural heart disease
Association of atrial fibrillation with survival in patients with low-flow low-gradient aortic stenosis with preserved ejection fraction undergoing transcatheter aortic valve implantation (TAVI)
Authors' conclusion
Patients with LFLG-pEF AS and AF experienced no relevant recovery of stroke volume after TAVI, but a more than two-fold increased risk of death compared to patients with HG AS or LFLG-pEF AS without AF.
Study context
- Population
- TAVI patients with preserved LVEF (≥ 50%), August 2007–June 2021444 LFLG-pEF AS, 765 HG AS
- Participants
- 2,259 patients
- Exposure
- Atrial fibrillation (AF) vs no AF in LFLG-pEF AS after TAVI
- LFLG-pEF AS with AFn = 190
- HG AS with AFn = 199
- Outcome
- All-cause mortality
- Follow-up
- 1 year
Methodological detailsprospective TAVI registry
- Prospective TAVI registry
Main finding
As reported in the abstract
Adjusted hazard ratio (95% CI)
LFLG-pEF AS with AFvs LFLG-pEF AS without AF
2.57(1.44–4.59)
LFLG-pEF AS without AFvs HG AS without AFsimilar mortality
0.85(0.49–1.46)
Observational data: associations, not effects.
Further findings
| Outcome | LFLG-pEF AS with AF | LFLG-pEF AS without AF |
|---|---|---|
| SVi, baseline to 1 year (LFLG-pEF AS) | 26.1 (SD 9.1) mL/m² | 37.2 (SD 9.9) mL/m² |
| Baseline | 26.8 ± 5.1 mL/m² | 25.9 ± 8.5 mL/m² |
Stroke volume index (SVi), baseline to 1 year (LFLG-pEF AS)
- SVi significantly improved without AF; remained low with AF
Original publication
Association of atrial fibrillation with survival in patients with low-flow low-gradient aortic stenosis with preserved ejection fraction undergoing TAVI. Eur Heart J Qual Care Clin Outcomes. Published 25 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →