Heart failure & cardiomyopathies
Race, hypertensive disorders of pregnancy and outcomes in peripartum cardiomyopathy
Authors' conclusion
In women with PPCM, poorer outcomes evident in Black women were driven by women without a history of HDP. In Black women, a history of HDP was associated with earlier presentation and recovery which was comparable to non-Black women.
Study context
- Population
- Women with peripartum cardiomyopathy (PPCM) enrolled in the IPAC study
- Participants
- 100 women
- Comparison
- Black women with hypertensive disorders of pregnancy (HDP) vs Black women without HDP
- Primary endpoint
- Myocardial recovery (LVEF by echocardiography)
- Follow-up
- 6 and 12 months postpartum
Primary result
As reported in the abstract
LVEF in Black women by HDP · 6 months postpartum
| Group | Value | Left ventricular ejection fraction (LVEF) at 12 months |
|---|---|---|
| HDP | 52 ± 11 % | 53 ± 10% |
| No HDP | 40 ± 14 % | 40 ± 16% |
Value
HDP52 ± 11 %
No HDP40 ± 14 %
Left ventricular ejection fraction (LVEF) at 12 months
HDP53 ± 10%
No HDP40 ± 16%
- HDP vs No HDP: P = 0.03 — 6 months
- HDP vs No HDP: P = 0.02 — 12 months
Further findings
| Outcome | HDP | No HDP | P value |
|---|---|---|---|
| Timing of presentation (days postpartum), Black womenHDP vs No HDP · earlier presentation with HDP | 34 ± 21 days | 54 ± 27 days | P = 0.03 |
- LVEF at 12 months, Black vs non-Black women · lower LVEF in Black women
- P < 0.001
- LVEF at 12 months, Black vs non-Black women · less recovery in Black women without HDP
- P < 0.001
- LVEF at 12 months, Black vs non-Black women · similar LVEF
- P = 0.56
Original publication
Race, hypertensive disorders of pregnancy and outcomes in peripartum cardiomyopathy. Am Heart J. Published 10 July 2024. doi:10.
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