Pulmonary vascular disease & thromboembolism
Randomized controlled trial of mechanical thrombectomy vs catheter-directed thrombolysis for acute hemodynamically stable pulmonary embolism: Rationale and design of the PEERLESS study
Study context
- Population
- Hemodynamically stable pulmonary embolism (PE) patients with right ventricular (RV) dysfunction and additional clinical risk factorsplanned
- Participants
- 550 patients
- Planned comparison
- Large-bore mechanical thrombectomy vs catheter-directed thrombolysis
- Primary endpoint
- Hierarchical win ratio composite:
- All-cause mortality
- Intracranial hemorrhage
- Major bleeding
- Clinical deterioration and/or escalation to bailout
- ICU admission
- Length of stay
- Follow-up
- Hospital discharge or 7 days post procedure, whichever is sooner
Methodological detailsrationale and design, multinational, 1:1 randomization, nonrandomized mechanical thrombectomy (MT) cohort for separate analysis, currently enrolling
- Rationale and design
- Multinational
- 1:1 randomization
- Nonrandomized MT cohort for separate analysis
- Currently enrolling
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Randomized controlled trial of mechanical thrombectomy vs catheter-directed thrombolysis for acute hemodynamically stable pulmonary embolism: Rationale and design of the PEERLESS study. Am Heart J. Published 12 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →