Randomized Trial of Bilateral versus Single Internal-Thoracic-Artery Grafts
Primary result · All-cause deathResult — go to the resultHazard ratio 1.04 95% CI 0.81–1.32Authors' conclusion
Among patients undergoing CABG, there was no significant difference between those receiving single internal-thoracic-artery grafts and those receiving bilateral internal-thoracic-artery grafts with regard to mortality or the rates of cardiovascular events at 5 years of follow-up. There were more sternal wound complications with bilateral internal-thoracic-artery grafting than with single internal-thoracic-artery grafting.
Study context
- Population
- Patients scheduled for coronary-artery bypass grafting (CABG), 28 cardiac surgical centres in 7 countries
- Participants
- 3,102 patients
- Comparison
- Bilateral vs single internal-thoracic-artery grafting in CABG
- Single-graftn = 1,554reference
- Bilateral-graftn = 1,548
- Primary endpoint
- All-cause death
- Follow-up
- 10 years
Methodological detailsmulticentre, prespecified interim analysis
- Multicentre
- Prespecified interim analysis
Primary result
As reported in the abstract
5 years
Hazard ratio
1.04
95% CI 0.81–1.32
P = 0.77
By group
Bilateral-graft vs Single-graft
HR 1.04 (95% CI 0.81–1.32); P = 0.77
Secondary outcomes
| Outcome | Single-graft | Bilateral-graft | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| All-cause death, MI or stroke · 5 years | 12.7% | 12.2% | 0.96 (0.79–1.17) | P = 0.69 | |
| 0.512Hazard ratio (log scale) |
Safety
Sternal wound complication
P = 0.005
Sternal reconstruction
P = 0.002
Original publication
Randomized Trial of Bilateral versus Single Internal-Thoracic-Artery Grafts. N Engl J Med. Published 14 November 2016. doi:10.
Summarised from the published abstract; every number is checked against it