Arrhythmias & electrophysiology
Rate control in atrial fibrillation, calcium channel blockers versus beta-blockers
Authors' conclusion
In patients with non-permanent AF, calcium channel blockers instituted for rate control were associated with less bradycardia during sinus rhythm compared with beta-blockers.
Study context
- Population
- Patients with non-permanent atrial fibrillation (AF) in sinus rhythm at baseline on rate control drugs, with AF during follow-upof 4060 AFFIRM patients
- Participants
- 474 patients
- Comparison
- Non-dihydropyridine calcium channel blockers vs beta-blockers for rate control
- Calcium channel blockersn = 218
- Beta-blockersn = 256reference
- Primary endpoint
- Heart rate during AF and during sinus rhythm
Primary result
As reported in the abstract
Resting heart rate <110 beats per min during AF
P = 1.00
Safety
Bradycardia during sinus rhythm · unadjusted
P < 0.001
| Outcome | OR (95% CI) | |
|---|---|---|
| Bradycardia during sinus rhythmAdjusted for patient characteristics | 0.41 (0.19–0.90) | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Rate control in atrial fibrillation, calcium channel blockers versus beta-blockers. Heart. Published 11 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →