Valvular & structural heart disease
Real-Time Biventricular Pressure-Volume Loops During Percutaneous Pulmonary Valve Implantation in Patients With RVOT Dysfunction
Authors' conclusion
Acute reduction of RV overload by PPVI is accompanied by an instantaneous decline in RV contractility with persistent and inefficient ventriculoarterial coupling. The LV adequately adapts to an increase in pre- and post-load with nonsignificant changes in LV intrinsic function and ventriculoarterial coupling.
Study context
- Population
- Patients with right ventricular (RV) outflow tract dysfunction (stenosis and pulmonary regurgitation) undergoing percutaneous pulmonary valve implantation (PPVI)
- Participants
- 20 patients
- Comparison
- Before vs directly after PPVI
- Outcome
- Acute changes in biventricular intrinsic myocardial function (pressure-volume loops by conductance catheter)
- Follow-up
- Before and directly after PPVI
Main finding
As reported in the abstract
Load-independent biventricular function, before vs directly after PPVI
- RV ventricular elastance, median [IQR], mm Hg/mL per m²: decreased after PPVI
- 0.26 [0.16-0.83] to 0.19 [0.13-0.42]; P=0.029
- Pulmonary arterial elastance, mean±SD, mm Hg/mL per m²: decreased after PPVI
- 0.32±0.20 to 0.25±0.19; P<0.001
- Right ventriculoarterial coupling, mean±SD: no significant change after PPVI
- 1.14±0.61 to 1.10±0.59; P=0.76
- Left ventricular (LV) ventricular elastance, mean±SD, mm Hg/mL per m²: not affected by PPVI
- 1.31±0.93 to 1.23±0.72; P=0.68
- Left ventriculoarterial coupling, median [IQR]: not affected by PPVI
- 0.75 [0.51-1.23] to 0.82 [0.53-1.10]; P=0.98
- Systemic arterial elastance, mean±SD, mm Hg/mL per m²: increased after PPVI
- 0.83±0.26 to 0.90±0.34; P=0.032
- RV compliance: no significant change after PPVI
- P=0.37
- LV compliance: no significant change after PPVI
- P=0.20
Further findings
Relevant pulmonary regurgitation (PR) (≥25%) vs minor PR (<25%) (subgroup)
- Lower RV ventricular elastance before PPVI with relevant PR
- P = 0.043
- Higher LV compliance after PPVI with relevant PR
- P = 0.010
- Ventriculoarterial coupling similar between the 2 groups
- n=10 per subgroup
Original publication
Real-Time Biventricular Pressure-Volume Loops During Percutaneous Pulmonary Valve Implantation in Patients With RVOT Dysfunction. Circ Heart Fail. Published 23 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →