Acute cardiac care & resuscitation
Real-time cerebral oximetry and outcomes during out-of-hospital resuscitation
Authors' conclusion
Greater values of rSO2 and ΔrSO2 identified instantaneous ROSC and predicted favorable neurological survival among those who achieved ROSC.
Study context
- Population
- Out-of-hospital cardiac arrest (OHCA) patients treated by Emergency Medical Services (EMS) in a suburban community140 eligible
- Participants
- 93 patients
- Exposure
- rSO2 by return of spontaneous circulation (ROSC) and by favourable survival
- ROSCn = 51
- Outcome
- Real-time rSO2 and ΔrSO2 upon ROSC vs time-matched ongoing pulselessness
Main finding
As reported in the abstract
AUC
0.84
P < 0.001
rSO2
AUC
0.85
P < 0.001
ΔrSO2
ROSC
- rSO2
- 60 %
- ΔrSO2
- 11 %
No ROSC
- rSO2
- 33 %
- ΔrSO2
- 1 %
rSO2
ROSC60 %
No ROSC33 %
ΔrSO2
ROSC11 %
No ROSC1 %
Observational data: associations, not effects.
Further findings
Initial rSO2 and subsequent ROSC · upon cerebral oximeter application · did not predict ROSC
AUC 0.61 · P = 0.13
| Outcome | AUC | P value |
|---|---|---|
| Initial rSO2 and subsequent favorable survival (CPC 1-2) · upon cerebral oximeter applicationCPC 1-2 vs no survival with CPC 1-2 · did not predict favorable survival | 0.77 | P = 0.17 |
| Real-time rSO2 and ΔrSO2 upon ROSC vs time-matched ongoing pulselessnessROSC vs ongoing pulselessness · rSO2 60 % vs 33 % | 0.84 | P < 0.001 |
| Real-time rSO2 and ΔrSO2 upon ROSC vs time-matched ongoing pulselessnessROSC vs ongoing pulselessness · ΔrSO2 11 % vs 1 % | 0.85 | P < 0.001 |
- Initial rSO2 and subsequent favorable survival (Cerebral Performance Category (CPC) 1-2): CPC 1-2 45 %
- Initial rSO2 and subsequent favorable survival (CPC 1-2): no survival with CPC 1-2 32 %
Peri-ROSC rSO2 and ΔrSO2 by subsequent favorable survival (among those with ROSC) · peri-ROSC period
- rSO2 greater with subsequent favorable survival: 63 % vs 46 %, AUC 0.74
- P = 0.06
- ΔrSO2 greater with subsequent favorable survival: 29 % vs 10 %, AUC 0.77
- P = 0.04
Original publication
Real-time cerebral oximetry and outcomes during out-of-hospital resuscitation. Resuscitation. Published 7 August 2025. doi:10.
Summarised from the published abstract; every number is checked against it