Heart failure & cardiomyopathiesCohort study
Real-World Evaluation of Individualised Natriuresis and Diuresis Driven Protocol for Decongestion in Acute Heart Failure
- retrospective study
- statistical adjustments for potential confounders
Authors' conclusion
This guided AHF protocol was associated with reduced hospital stays, six-month rehospitalisation rates, and mortality. Tailoring individual optimised diuretic therapy for ADHF seems promising, but further research is needed to confirm its long-term benefits.
Study context
- Population
- Patients with acute decompensated heart failure (ADHF) at Maastricht University Medical Centre+ (MUMC+)
- Exposure
- Guided protocol vs Standard care
Main finding
As reported in the abstract
P = 0.029
Observational data: associations, not effects.
Further findings
Mortality · six months · lower with guided protocol · independent of baseline differences and confounders
P = 0.017
Cardiac rehospitalisation · six months · lower with guided protocol · independent of baseline differences and confounders
P = 0.015
Cardiac rehospitalisation and mortality · 12 months
- sustained association of reduced cardiac rehospitalisation rates and a trend toward lower mortality
Original publication
Summarised from the published abstract; every number is checked against it