Valvular & structural heart diseaseCohort study
Recommended Criteria to Define Right Ventricular Dysfunction in Severe Secondary Tricuspid Regurgitation
- Retrospective cohort study
- consecutive patients
Authors' conclusion
The TVARC and ASE cutoffs for RV dysfunction showed prognostic value in patients with significant STR.
Study context
- Population
- Patients with ≥ moderate-to-severe secondary tricuspid regurgitation (STR)
- Participants
- 1,550 patients
- Exposure
- TVARC and ASE echocardiographic cutoffs for right ventricular (RV) dysfunction
- Outcome
- Composite of:
- All-cause mortality and HF hospitalization
- Censored for tricuspid valve intervention
- Follow-up
- Median 22 months (Q1-Q3: 3-63 months)
Main finding
As reported in the abstract
- All-cause mortality
- HF hospitalization
Patients reaching the composite endpoint
703 (45%)
Stepwise combined grading using tricuspid annular plane systolic excursion (TAPSE) and right ventricular free wall longitudinal strain (RVFWLS) showed the strongest association with the composite endpoint; mild, moderate and severe grades independently associated (TVARC cutoffs)
P < 0.001
Mild, moderate and severe grades of combined TAPSE and RVFWLS grading independently associated (ASE cutoffs)
P < 0.005
Observational data: associations, not effects.
Original publication
Summarised from the published abstract; every number is checked against it