Valvular & structural heart disease
Cusp overlap versus standard three-cusp technique for self-expanding Evolut transcatheter aortic valves
Main finding · PPIResult — go to the resultOdds ratio 0.63 95% CI 0.49–0.82Authors' conclusion
The introduction of the COT was associated with a significant and relevant reduction of PPI and paravalvular regurgitation rates without an increase in complication rates.
Study context
- Population
- All-comers undergoing transcatheter aortic valve implantation (TAVI) with the self-expanding Evolut platform at five sites, January 2016 to April 2022
- Participants
- 2,209 participants
- Exposure
- Cusp overlap technique (COT) vs 3CT for self-expanding Evolut TAVI
- COTn = 1,058
- 3CTn = 1,151reference
- Outcome
- Incidence of PPI
- Follow-up
- Discharge
Methodological detailsmulticentre, propensity-score matched
- Multicentre
- Propensity-score matched
Main finding
PPI
Odds ratio
0.63
95% CI 0.49–0.82
P < 0.001
By group
3CT
17.0
%
COT
12.3%
COTvs 3CT
OR 0.63 (95% CI 0.49–0.82); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
Moderate/severe paravalvular regurgitation · discharge · unmatched cohort
P = 0.006
Predictors of permanent pacemaker implantation (PPI) (multivariable)
- Right bundle branch block: OR 7.19 (95% CI 5.18-10.0)
- P < 0.001
- DM: OR 1.38 (95% CI 1.05-1.80)
- P = 0.021
Overall procedural success
- Similar in the two groups
Safety
Major bleeding
P = 0.020
Major bleeding
- Overall complication rates similar
Original publication
Cusp overlap versus standard three-cusp technique for self-expanding Evolut transcatheter aortic valves. EuroIntervention. Published 5 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →