Cohort study
Reduced Stress-Related Neural Network Activity Mediates the Effect of Alcohol on Cardiovascular Risk
- Cohort study with mediation analysis
- biobank-based
- 18F-FDG PET subset
Authors' conclusion
ACl/m associates with reduced MACE risk, in part, by lowering activity of a stress-related brain network known for its association with cardiovascular disease.
Study context
- Population
- Mass General Brigham Biobank participants who completed a health behavior survey713 with brain imaging
- Participants
- 53,064 participants
- Exposure
- Light/moderate vs none/minimal alcohol consumption
- None/minimaln = 23,920reference
- ACl/mn = 27,053
- Outcome
- Whether the association between light/moderate alcohol consumption and MACE is mediated by decreased stress-related neural network activity (SNA)
- Follow-up
- Median 3.4 years
Main finding
As reported in the abstract
MACE
ACl/m vs None/minimalHazard ratio (95% CI)P value
adjusted for CV risk factors
0.786(0.717–0.862)
P < 0.0001- mediation of major adverse cardiovascular events (MACE) effect by lower SNA (partial)
- log OR −0.040 (95% CI −0.097 to −0.003); P < 0.05
- MACE events
- 1,914
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| MACE, by prior anxiety (subgroup) — ACl/m vs None/minimal · with prior anxiety | 0.60 (0.50–0.72) | ||
| MACE, by prior anxiety (subgroup) — ACl/m vs None/minimal · without prior anxiety | 0.78 (0.73–0.80) | ||
| 0.512Hazard ratio (log scale) |
| Outcome | standardized beta (95% CI) | P value |
|---|---|---|
| SNA (713 with brain imaging) | −0.192 (−0.338 to −0.046) | P = 0.01 |
- MACE, by prior anxiety (subgroup): P interaction = 0.003
Original publication
Reduced Stress-Related Neural Network Activity Mediates the Effect of Alcohol on Cardiovascular Risk. J Am Coll Cardiol. Published 20 June 2023. doi:10.1016/j.jacc.2023.04.015
Summarised from the published abstract; every number is checked against it