Refined physical activity recommendations considering cardiovascular disease risk stratification: a cohort study
Authors' conclusion
The optimal VPA threshold should be underscored, especially for high- or very high-risk populations.
Study context
- Population
- UK Biobank participants with accelerometer-derived physical activity (PA) and sedentary time
- Participants
- 72,884 participants
- Exposure
- Accelerometer-derived PA across SCORE2 risk strata
- Outcome
- Incident CVD
Methodological detailsUK Biobank, accelerometer-derived PA, compositional data analysis
- UK Biobank
- Accelerometer-derived PA
- Compositional data analysis
Main finding
As reported in the abstract
Incident CVD per 150-min/week increase in MVPA, by risk stratum
| Group | Lower hazard |
|---|---|
| Very high risk | 20% (95% CI 14-26%) |
| High risk | 16% (14-18%) |
| Low-to-moderate risk | 16% (13-19%) |
Lower hazard
Very high risk20% (95% CI 14-26%)
High risk16% (14-18%)
Low-to-moderate risk16% (13-19%)
Observational data: associations, not effects.
Further findings
Reallocating sedentary time to moderate-to-vigorous PA (MVPA) (compositional analysis)
- Low-to-moderate risk: replacing 300 min/week of sedentary time with any MVPA combination provided benefits
- High risk: benefits may diminish beyond VPA of 60 min/week
- Very high risk: benefits may diminish beyond VPA of 42 min/week
Original publication
Refined physical activity recommendations considering cardiovascular disease risk stratification: a cohort study. Eur J Prev Cardiol. Published 28 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →