Heart failure & cardiomyopathies
Regional Differences and Coronary Microvascular Dysfunction in Heart Failure with Preserved Ejection Fraction
Authors' conclusion
Despite regional differences in clinical characteristics, CMD was present in the majority of patients with HFpEF across different regions of the world with the lowest prevalence in the United States. This difference was explained by differences in patient characteristics.
Study context
- Population
- Patients with stable heart failure with preserved ejection fraction (HFpEF) (LVEF ≥40%) without unrevascularized macrovascular CAD, in Finland, Singapore, Sweden and US
- Participants
- 202 patients
- Exposure
- Coronary microvascular dysfunction (CMD) prevalence by region
- Outcome
- Prevalence of CMD (Doppler echocardiography coronary flow reserve <2.5)
Methodological detailsmulticentre, PROMIS-HFpEF study
- Multicentre
- PROMIS-HFpEF study
Main finding
As reported in the abstract
CMD prevalence
Observational data: associations, not effects.
Further findings
Associations between CMD and clinical characteristics by region
- Did not differ based on region (interaction analysis)
Original publication
Regional Differences and Coronary Microvascular Dysfunction in Heart Failure with Preserved Ejection Fraction. ESC Heart Fail. Published 2 November 2023. doi:10.
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