Regional variation in cause of death in patients with type 2 diabetes: Insights from EXSCEL
Authors' conclusion
In a contemporary T2D trial population, with and without established CVD, leading causes of death varied by geographic region.
Study context
- Population
- Patients with T2DM at risk for cardiovascular disease (CVD) (73% with established CVD)
- Participants
- 14,752 patients
- Primary endpoint
- Cause-specific deaths (CV and non-CV) by geographic region
- Follow-up
- median 3.2-year follow-up
Methodological detailsinternational
- International
Primary result
As reported in the abstract
- All-cause deaths
- 1,091 (7.4%)
- CV deaths (incl. 252 unknown)
- 723 (66.3% of deaths)
- Non-CV deaths
- 368 (33.7%)
- Deaths in North America
- N = 356/9.6% across region
- Deaths in Eastern Europe
- N = 326/8.1%
- Deaths in Asia/Pacific (fewest)
- N = 68/4.4%
- Leading cause Asia/Pacific: sudden cardiac
- 23/34% of regional deaths
- Leading cause North America: sudden cardiac
- 86/24%
- Leading cause Eastern Europe: unknown
- 90/28%
- Leading cause Western Europe: unknown
- 39/21%
- Leading cause Latin America: non-malignant non-CV
- 48/31%
Further findings
Prognostic risk factors for adjudicated CV and non-CV death (Cox model)
| HR (95% CI) | ||
|---|---|---|
| Heart failureCV death | 2.04 (1.72–2.42) | |
| Heart failurenon-CV death | 1.86 (1.46–2.39) | |
| Peripheral artery diseaseCV death | 1.83 (1.54–2.18) | |
| Peripheral artery diseasenon-CV death | 1.78 (1.40–2.26) | |
| Current smoking statusCV death | 1.61 (1.29–2.01) | |
| Current smoking statusnon-CV death | 1.77 (1.31–2.40) | |
| 0.512Hazard ratio (log scale) |
Original publication
Regional variation in cause of death in patients with type 2 diabetes: Insights from EXSCEL. Am Heart J. Published 22 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →