Cohort study
Relation of Left Ventricular Diastolic Function to Global Fibrosis Burden
- Cohort study
Authors' conclusion
Higher grades of diastolic dysfunction are seen in patients with replacement fibrosis and increased ECV. Fibrosis burden as determined with the use of CMR provides incremental prognostic information to echocardiographic evaluation of LV diastolic function.
Study context
- Population
- Patients undergoing comprehensive echocardiography and cardiac magnetic resonance (CMR) within 30 days18 (3.3%) indeterminate
- Participants
- 549 patients
- Exposure
- Diastolic dysfunction vs Normal diastolic function
- Normal diastolic functionn = 142reference
- Outcome
- Composite of:
- Total mortality
- HF hospitalizations
Main finding
As reported in the abstract
Composite outcome:
- Total mortality
- HF hospitalization
Diastolic dysfunction
33.4%
Normal diastolic function
15.5
P < 0.001
- C-statistic, model with left ventricular (LV) diastolic function grades II and III
- 0.71 (95% CI 0.67-0.76)
- C-statistic, after adding global fibrosis burden
- 0.74 (95% CI 0.70-0.78; P = 0.02)
Observational data: associations, not effects.
Further findings
HF hospitalizations (competing risk model)
- C-statistic, LV diastolic function grades II and III
- 0.78 (95% CI 0.74-0.83)
- C-statistic, after adding global fibrosis burden
- 0.80 (95% CI 0.76-0.85; P = 0.03)
Original publication
Relation of Left Ventricular Diastolic Function to Global Fibrosis Burden. JACC Cardiovasc Imaging. Published 8 March 2023. doi:10.1016/j.jcmg.2022.12.027
Summarised from the published abstract; every number is checked against it