Heart failure & cardiomyopathies
Combination of an implantable defibrillator multi-sensor heart failure index and an apnea index for the prediction of atrial high-rate events
Authors' conclusion
In HF patients, the occurrence of AHRE is independently associated with the ICD-measured IN-alert HF state and RDI ≥ 30 episodes/h. The coexistence of these two conditions occurs rarely but is associated with a very high rate of AHRE occurrence.
Study context
- Population
- Heart failure (HF) patients with ICDconsecutive HF patients with ICD
- Participants
- 411 patients
- Exposure
- IN-alert HF state and severe sleep apnoea (SA) vs neither
- Outcome
- Daily AHRE burden of ≥5 min, ≥6 h and ≥23 h
- Follow-up
- Median 26 months
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
AHRE
Hazard ratio (95% CI)P value
RDI ≥ 30 episodes/hAHRE ≥5 min/day only
1.55(1.11–2.16)
P = 0.001- IN-alert HF state · atrial high-rate events (AHRE) ≥5 min/day; independently associated
- HR 2.17; P < 0.01
- IN-alert HF state · AHRE ≥23 h/day; independently associated
- HR 3.43; P < 0.01
- AHRE burden ≥5 min/day
- 139 (34%) patients
- AHRE burden ≥6 h/day
- 89 (22%) patients
- AHRE burden ≥23 h/day
- 68 (17%) patients
- Time IN-alert HF state, % of observation period
- 13%
- Time with Respiratory Disturbance Index (RDI) ≥30 episodes/h, % of observation period
- 58%
Observational data: associations, not effects.
Further findings
AHRE rate with combined IN-alert HF state and RDI ≥30 episodes/h
- Combination, % of follow-up period
- 6%
- AHRE burden ≥5 min/day
- 28 events/100 patient-years
- AHRE burden ≥23 h/day
- 22 events/100 patient-years
Original publication
Combination of an implantable defibrillator multi-sensor heart failure index and an apnea index for the prediction of atrial high-rate events. Europace. Published 7 March 2023. doi:10.
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