Valvular & structural heart disease
Relationship between baseline patient-reported health status and patient-centered outcomes after transcatheter aortic valve replacement
Authors' conclusion
In this post hoc analysis of SCOPE I, better baseline patient-reported health status was associated with a higher probability of being alive with good health status up to 3 years after TAVR.
Study context
- Population
- Patients with symptomatic severe aortic stenosis (AS) who underwent transfemoral transcatheter aortic valve replacement (TAVR) and provided baseline Kansas City Cardiomyopathy Questionnaire (KCCQ) assessmentOf 739 patients enrolled in SCOPE I
- Participants
- 692 patients
- Comparison
- Higher baseline KCCQ-OS vs 0-25
- KCCQ-OS < 25n = 74
- 25 to 49n = 222
- 50 to 74n = 271
- ≥ 75n = 125
Methodological detailsinvestigator-initiated, multicenter SCOPE I randomized trial
- Investigator-initiated, multicenter SCOPE I randomized trial
Primary result
As reported in the abstract
Baseline KCCQ-OS
- Median baseline KCCQ-OS
- 54.9 (39.6-71.9)
Further findings
| Outcome | Adjusted odds ratio (95% CI) | |
|---|---|---|
| Alive with good health status · 3 years after TAVRKCCQ-OS 50-75vs 0-25 | 2.25 (1.12–4.54) | |
| Alive with good health status · 3 years after TAVR75-100vs 0-25 | 5.15 (2.33–11.3) | |
| 0.050.21520Adjusted odds ratio (log scale) |
All-cause mortality, and alive with good health status
- Restricted cubic spline modelling demonstrated an approximately linear relationship between baseline KCCQ-OS and all-cause mortality, and alive with good health status
Original publication
Relationship between baseline patient-reported health status and patient-centered outcomes after transcatheter aortic valve replacement. Am Heart J. Published 26 May 2026. doi:10.
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