Heart failure & cardiomyopathies
Relationship Between Haemodynamic Indicators and Haemogram in Patients with Heart Failure
Authors' conclusion
LVEDP, CI, plasma Nor concentration, and eGFR were related to WBC count, Hb level, and Plt count in patients with heart failure. There was a strong relationship between elevated LVEDP and decreased Plt count, suggesting that pressure overload on the lungs may interfere with the function of the lung as a site of Plt biosynthesis.
Study context
- Population
- Patients with HF undergoing cardiac catheterization for evaluation of cardiac function, 2015–2020251 (73%) men
- Participants
- 345 patients
- Outcome
- Relationship between haemodynamic indicators (LVEDP, cardiac index), plasma noradrenaline, eGFR and haemogram (WBC count, Hb level, Plt count)
Methodological detailsstructural equation modelling, Bayesian inference, Mean age 66.0 ± 13.2 years
- Structural equation modelling
- Bayesian inference
- Mean age 66.0 ± 13.2 years
Main finding
As reported in the abstract
SEM relationships between haemodynamic indicators and haemogram
- Left ventricular end-diastolic pressure (LVEDP) vs platelet (Plt) count: significant negative relationship (standardized estimate)
- −0.129, P = 0.015
- Cardiac index vs haemoglobin (Hb) level: significant negative relationship (standardized estimate)
- −0.263, P < 0.001
- Plasma noradrenaline vs white blood cell (WBC) count: significant positive relationship (standardized estimate)
- 0.165, P = 0.003
- Plasma noradrenaline vs Plt count: significant positive relationship (standardized estimate)
- 0.198, P < 0.001
- Estimated glomerular filtration rate (eGFR) vs Hb level: significant positive relationship (standardized estimate)
- 0.274, P < 0.001
Observational data: associations, not effects.
Further findings
Bayesian inference using structural equation modelling (SEM)
- No relationship between LVEDP and Hb level or WBC count; significant negative relationship between LVEDP and Plt count
Original publication
Relationship Between Haemodynamic Indicators and Haemogram in Patients with Heart Failure. ESC Heart Fail. Published 7 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →