Relationship between left ventricular shape and cardiovascular risk factors: comparison between the Multi-Ethnic Study of Atherosclerosis and UK Biobank
Authors' conclusion
The MESA and UKB atlases demonstrated good generalisability for diabetes and hypercholesterolaemia, without requiring corrections for differences in mass and volume.
Study context
- Population
- Participants with cardiac MRI from Multi-Ethnic Study of Atherosclerosis (MESA) and UK Biobank with differing CV risk factor profiles
- Participants
- 2,106 vs 2,960
- Exposure
- Internal vs external discriminative performance of left ventricular (LV) shape atlases
- MESAn = 2,106
- UK Biobank (UKB)n = 2,960
- Outcome
- Generalisability of LV shape atlases per risk factor: AUC not significantly different (p>0.05) between internal and external cases
Methodological detailstwo cohorts, statistical shape atlases
- Two cohorts
- Statistical shape atlases
Main finding
As reported in the abstract
AUC, internal vs external
- UKB atlas, hypertension: AUC internal vs external
- 0.77 vs 0.76, p=0.37
- UKB atlas, diabetes: AUC internal vs external
- 0.79 vs 0.77, p=0.48
- UKB atlas, hypercholesterolaemia: AUC internal vs external
- 0.76 vs 0.79, p=0.38
- UKB atlas, smoking: AUC internal vs external
- 0.69 vs 0.67, p=0.18
- MESA atlas, diabetes: AUC internal vs external
- 0.79 vs 0.74, p=0.09
- MESA atlas, hypercholesterolaemia: AUC internal vs external
- 0.75 vs 0.70, p=0.10
Observational data: associations, not effects.
Further findings
LV mass and volume indices
- Differed significantly between cohorts, even in age- and sex-matched cases without risk factors, partly reflecting different core lab protocols
Original publication
Relationship between left ventricular shape and cardiovascular risk factors: comparison between the Multi-Ethnic Study of Atherosclerosis and UK Biobank. Heart. Published 16 January 2025. doi:10.
Summarised from the published abstract; every number is checked against it