Arrhythmias & electrophysiology
Relationship Between Periodontitis and Atrial Fibrosis in Atrial Fibrillation: Histological Evaluation of Left Atrial Appendages
Authors' conclusion
The authors histologically revealed the association of periodontitis with atrial fibrosis.
Study context
- Population
- Patients with atrial fibrillation (AF) scheduled for LAA excision during cardiac surgery55 nonparoxysmal AF
- Participants
- 76 patients
- Exposure
- Periodontitis parameters vs degree of atrial fibrosis
- Outcome
- Association of periodontitis parameters (bleeding on probing, periodontal probing depth, PISA) with atrial fibrosis (Azan-Mallory staining)
Methodological detailshistological analysis of resected left atrial appendages (LAAs)
- Histological analysis of resected LAAs
Main finding
As reported in the abstract
Correlation with atrial fibrosis
- Bleeding on probing, R = 0.48
- P < 0.0001
- Periodontal probing depth ≥4 mm, R = 0.26
- P = 0.02
- Periodontal inflamed surface area (PISA), R = 0.46
- P < 0.0001
- PISA, adjusted (age, AF duration, BMI, mitral regurgitation, CHADS₂), β = 0.016
- P = 0.0002
Observational data: associations, not effects.
Further findings
PISA vs atrial fibrosis in patients with >10 remaining teeth (subgroup)
- R = 0.57
- P < 0.0001
Original publication
Relationship Between Periodontitis and Atrial Fibrosis in Atrial Fibrillation: Histological Evaluation of Left Atrial Appendages. JACC Clin Electrophysiol. Published 31 October 2022. doi:10.
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