Arrhythmias & electrophysiology
Predictors of stroke volume improvement with atrioventricular (AV)-optimized conduction system pacing in patients with AV dromotropathy
Authors' conclusion
Echocardiographically assessed mechanical AV dyssynchrony, rather than electrocardiographic parameters, is associated with an acute haemodynamic response to pacing. Echocardiographic evaluation may help identify patients with prolonged PR interval who could benefit from AV-optimized CSP.
Study context
- Population
- Patients with symptomatic first-degree AV blockmean age 60.5 ± 21.1 years, 37% female
- Participants
- 19 patients
- Comparison
- Electrocardiographic parameters (PR interval, P wave duration/PR interval ratio) and echocardiographic indices (E/A wave confluence, A-Q interval, and DFT/RR ratio) tested for association with change in left ventricular stroke volume (LVSV)
- Outcome
- Baseline parameters
- Follow-up
- Baseline
Main finding
As reported in the abstract
Mean PR interval
395 ± 61 ms
Mean A-Q interval
155 ± 65 ms
Mean DFT/RR ratio
0.34 ± 0.1
E/A wave confluence present
15 patients
79%
Further findings
Change in LVSV with AV-optimized pacing
- LVSV increase
- 7.8 ± 3.9 ml
- Relative increase
- 11.8 ± 5.7%
- P
- P < 0.01
Association of echocardiographic parameters with LVSV response
- A-Q interval
- r = 0.63, P = .004
- DFT/RR ratio
- r = −0.59, P = .008
- E/A wave confluence
- r = 0.57, P = .01
Association of electrocardiographic parameters with LVSV change
- Electrocardiographic parameters were not associated with LVSV change
Original publication
Predictors of stroke volume improvement with AV-optimized conduction system pacing in patients with AV dromotropathy. ESC Heart Fail. Published 19 February 2026. doi:10.
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