Relationship Between Urinary Uranium and Cardiac Geometry and Left Ventricular Function: The Strong Heart Study
Authors' conclusion
Urinary uranium levels were adversely associated with measures of cardiac geometry and LV function among American Indian adults, including increases in pulse pressure and LV hypertrophy.
Study context
- Population
- American Indian young adults (<50 years, free of DM and CVD) from the Strong Heart Family Study
- Participants
- 1,332 adults
- Exposure
- Urinary uranium and cardiac geometry and function
- Outcome
- Echocardiographic cardiac geometry and function measures and BP
- Follow-up
- Baseline (2001-2003) and (2006-2009)
Methodological detailslinear mixed-effect models
- Linear mixed-effect models
Main finding
As reported in the abstract
- Median (IQR) urinary uranium
- 0.029 (0.045) μg/g creatinine
- Left ventricular (LV) mass index at baseline, mean difference
- 0.49 g/m² (0.07-0.92 g/m²) (95% CI)
- Left atrial systolic diameter at baseline
- 0.01 cm/m² (0.01-0.02 cm/m²) (95% CI)
- Stroke volume at baseline
- 0.66 mL (0.25-1.08 mL) (95% CI)
- Prospective increase in left atrial diameter
- 0.01 cm/m² (0.01-0.02 cm/m²) (95% CI)
- Prospective increase in pulse pressure
- 0.28 mm Hg (0.05-0.52 mm Hg) (95% CI)
- Incident LV hypertrophy, OR
- 1.25 (1.06, 1.48) (95% CI)
Observational data: associations, not effects.
Original publication
Relationship Between Urinary Uranium and Cardiac Geometry and Left Ventricular Function: The Strong Heart Study. JACC Adv. Published 19 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →