Relationship of Coronary Angiography-Derived Radial Wall Strain With Functional Significance, Plaque Morphology, and Clinical Outcomes
Authors' conclusion
RWS was associated with coronary physiology and plaque morphology but showed independent prognostic significance.
Study context
- Population
- Vessels deferred after fractional flow reserve (FFR) measurement with available radial wall strain (RWS) data and coronary CT angiography
- Participants
- 351 participants484 vessels
- Outcome
- TVF (target vessel revascularization, target vessel MI or cardiac death)
Main finding
As reported in the abstract
TVF per increment of RWSmax
- HR per increment of RWSmax for target vessel failure (TVF)
- 1.23 (95% CI: 1.03-1.47); P = 0.022
- Optimal RWSmax cutoff
- 14.25%
- RWSmax >14% predictor of TVF after adjustment for FFR or high-risk plaque (HRP) components
- all P < 0.05
Observational data: associations, not effects.
Further findings
Baseline FFR, RWSmax, HRP and FFR ≤0.80
- Mean FFR
- 0.89 ± 0.07
- Mean RWSmax
- 11.2% ± 2.5%
- Lesions with HRP
- 27.7%
- Lesions with FFR ≤0.80
- 15.1%
- HRP: minimum lumen area <4 mm² and plaque burden ≥70% on coronary CT angiography
Association of RWSmax with FFR ≤0.80 and HRP
- Higher RWSmax associated with higher risk of FFR ≤0.80 and HRP, consistent after adjustment
- all P < 0.05
TVF when high RWSmax added to FFR ≤0.80 or HRP
- Increasing outcome trends
- all P for trend <0.001
Original publication
Relationship of Coronary Angiography-Derived Radial Wall Strain With Functional Significance, Plaque Morphology, and Clinical Outcomes. JACC Cardiovasc Interv. Published 8 January 2024. doi:10.
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