Pulmonary vascular disease & thromboembolism
Relationship of Tricuspid Annular Plane Systolic Excursion (TAPSE) Normalized by Right Ventricular Area With Pulmonary Compliance, Exercise Capacity, and Clinical Outcomes
Authors' conclusion
In a broad cohort with suspected pulmonary hypertension, TAPSE divided by RV area was superior to TAPSE alone in correlations with pulmonary compliance and exercise capacity. As a prognostic marker of right heart function, TAPSE/RVA-D <1.1 and TAPSE/RVA-S <1.5 predicted adverse cardiovascular outcomes.
Study context
- Population
- Subjects with NYHA class II–III dyspnoea undergoing echocardiogram and invasive cardiopulmonary exercise testing (suspected pulmonary hypertension)
- Participants
- 71 subjects
- Exposure
- TAPSE/RVA-D and TAPSE/RVA-S vs TAPSE
- Outcome
- Correlation with pulmonary artery compliance and peak VO2 % predicted; identification of pulmonary artery compliance ≥3 mL/mm Hg; death or CV hospitalization
Methodological detailsAnalyses: Pearson correlation, linear regression, ROC and survival curves
- Analyses: Pearson correlation, linear regression, ROC and survival curves
Main finding
As reported in the abstract
| Group | Pulmonary artery compliance ≥3 mL/mm Hg AUC | Optimal cutoff | Correlation with pulmonary artery compliance (r) | Correlation with peak VO2 % predicted |
|---|---|---|---|---|
| TAPSE/RVA-D | 0.79 | ≥1.1 | ||
| TAPSE/RVA-S | 0.83 | ≥1.5 | ||
| TAPSE | 0.67 | 0.38 | 0.18 |
Pulmonary artery compliance ≥3 mL/mm Hg AUC
TAPSE/RVA-D0.79
TAPSE/RVA-S0.83
TAPSE0.67
Optimal cutoff
TAPSE/RVA-D≥1.1
TAPSE/RVA-S≥1.5
TAPSE— not stated in the abstract
Correlation with pulmonary artery compliance (r)
TAPSE/RVA-D— not stated in the abstract
TAPSE/RVA-S— not stated in the abstract
TAPSE0.38
Correlation with peak VO2 % predicted
TAPSE/RVA-D— not stated in the abstract
TAPSE/RVA-S— not stated in the abstract
TAPSE0.18
- TAPSE/RVA metrics correlation with pulmonary artery compliance (r)
- 0.48-0.54
- TAPSE/RVA metrics correlation with peak VO2 % predicted
- 0.23-0.30
Observational data: associations, not effects.
Further findings
Death or CV hospitalization · 12 months
| HR (95% CI) | ||
|---|---|---|
| TAPSE/RVA-D ≥1.1 | 0.38 (0.11–0.56) | |
| TAPSE/RVA-S ≥1.5 | 0.44 (0.16–0.78) | |
| TAPSENot associated with adverse outcomes | 0.99 (0.53–1.94) | |
| 0.10.31310Hazard ratio (log scale) |
| Outcome | TAPSE/RVA-D | TAPSE/RVA-S | TAPSE |
|---|---|---|---|
| Identification of peak VO2 <50% predicted | |||
| AUC | 0.66 | 0.65 | — not stated in the abstract |
| Correlation with RV EF on CMR (subgroup) | |||
| R | 0.378 | 0.328 | 0.082 |
— not stated in the abstract
- Correlation with right ventricle (RV) EF on CMR (subgroup): 31 subjects with available CMR
Original publication
Relationship of TAPSE Normalized by Right Ventricular Area With Pulmonary Compliance, Exercise Capacity, and Clinical Outcomes. Circ Heart Fail. Published 6 May 2024. doi:10.
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