Remnant cholesterol predicts cardiovascular disease beyond LDL and ApoB: a primary prevention study
Authors' conclusion
In ASCVD-free individuals, elevated RC levels were associated with ASCVD independent of traditional risk factors, LDL-C, and apoB levels.
Study context
- Population
- Atherosclerotic cardiovascular disease (ASCVD)-free individuals (primary prevention)2,143 ASCVD events
- Participants
- 17,532 individuals
- Comparison
- Log remnant cholesterol (RC) levels; RC vs low-density lipoprotein cholesterol (LDL-C) discordant/concordant groups
- Outcome
- Incident ASCVD
- Follow-up
- Median 18.7 years
Methodological detailsARIC, MESA and CARDIA cohorts, discordance analysis
- ARIC, MESA and CARDIA cohorts
- Discordance analysis
Pooled result
As reported in the abstract
Hazard ratio (95% CI)
Log RCadjusted incl. LDL-C and apoB
1.65(1.45–1.89)
High RC/low LDL-C vs Concordant
1.21(1.08–1.34)
Further pooled results
Discordance across clinical LDL-C cutpoints
- Similar results
Original publication
Remnant cholesterol predicts cardiovascular disease beyond LDL and ApoB: a primary prevention study. Eur Heart J. Published 19 July 2021. doi:10.
Summarised from the published abstract; every number is checked against it