Heart failure & cardiomyopathiesSecondary analysis
Remote Patient Management of Heart Failure Across the Ejection Fraction Spectrum: A Pre-Specified Analysis of the TIM-HF2 Trial
- Secondary analysis of the TIM-HF2 randomised trial
- pre-specified analysis
- prospective
- multicentre
Authors' conclusion
In the clinical set-up deployed in the TIM-HF2 trial, RPM appeared effective irrespective of the LVEF-based HF phenotype.
Study context
- Population
- Patients hospitalized for heart failure (HF) within 12 months before randomization, by left ventricular ejection fraction (LVEF): ≤40% (HFrEF), 41–49% (HFmrEF), ≥50% (HFpEF)818 HFrEF, 224 HFmrEF, 496 HFpEF
- Participants
- 1,538 patients
- Comparison
- Structured remote patient management vs usual care, by LVEF subgroup
- Primary endpoint
- Percentage of days lost due to all-cause death or unplanned CV hospitalization
Primary result
As reported in the abstract
Percentage of days lost due to all-cause death or unplanned CV hospitalisation, by LVEF subgroup
intervention vs controlIncidence rate ratio (95% CI)
HFrEF (LVEF ≤40%): 5.4% vs 7.6% days lost
0.72(0.54–0.97)
HFmrEF (LVEF 41-49%): 3.3% vs 5.9% days lost
0.85(0.48–1.50)
HFpEF (LVEF ≥50%): 4.7% vs 5.4% days lost
0.93(0.64–1.36)
Secondary outcomes
All-cause and CV mortality (key secondary), by LVEF subgroup
- Reduced by remote patient management (RPM) in each subgroup, HRs <1.0 across the LVEF spectrum for both endpoints
Original publication
Remote Patient Management of Heart Failure Across the Ejection Fraction Spectrum: A Pre-Specified Analysis of the TIM-HF2 Trial. Eur J Heart Fail. Published 31 July 2023. doi:10.1002/ejhf.2948
Summarised from the published abstract; every number is checked against it