Heart failure & cardiomyopathies
Renin angiotensin system inhibitors and outcome in patients with takotsubo syndrome: A propensity score analysis of the GEIST registry
Main finding · MortalityResult — go to the resultHazard ratio 0.63 95% CI 0.45–0.87Authors' conclusion
Long-term therapy with RASi after a TTS episode was not associated with lower mortality rates at propensity score analysis. However, potential survival benefit can be found among patients with admission LVEF ≤ 40% or diabetes.
Study context
- Population
- TTS patients discharged alive, GEIST registrydischarged alive
- Participants
- 2,453 patients
- Exposure
- Renin Angiotensin system inhibitors (RASi) vs no RASi at discharge after TTS
- RASin = 1,683
- Outcome
- Long-term mortality
- Follow-up
- Median 31 (IQR 12-56) months
Methodological detailsinternational multicenter registry, propensity score matched (1:1)
- International multicenter registry
- Propensity score matched (1:1)
Main finding
Mortality · long term
Hazard ratio
0.63
95% CI 0.45–0.87
P < 0.01
RASivs No RASi
HR 0.63 (95% CI 0.45–0.87); P < 0.01
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Mortality, admission LVEF ≤ 40% (subgroup)Overall cohort | 0.54 (0.38–0.78) | P = 0.001 | |
| Mortality, admission LVEF ≤ 40% (subgroup)Matched cohort | 0.59 (0.37–0.95) | P = 0.030 | |
| Mortality, diabetes (subgroup)Overall cohort | 0.41 (0.23–0.73) | P = 0.002 | |
| Mortality, diabetes (subgroup)Matched cohort | 0.41 (0.21–0.82) | P = 0.011 | |
| 0.20.5125Hazard ratio (log scale) |
In-hospital complications · baseline characteristic
P < 0.01
Original publication
Renin angiotensin system inhibitors and outcome in patients with takotsubo syndrome: A propensity score analysis of the GEIST registry. Am Heart J. Published 10 September 2024. doi:10.
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