Repeatability and Correlation of Coronary Physiology Indices Measured With Bolus and Continuous Thermodilution
Authors' conclusion
In cardiac transplant recipients, IMR had superior repeatability compared with CFR and MRR derived from either bolus or continuous thermodilution, and was equally repeatable compared with R Hyp . FFR, CFR, and MRR values obtained from continuous thermodilution were systematically lower compared with their counterparts obtained from bolus thermodilution.
Study context
- Population
- Cardiac transplant recipients
- Participants
- 20 patients
- Comparison
- Continuous thermodilution vs bolus thermodilution
- Outcome
- Repeatability (intraclass correlation coefficient): IMR vs CFR and MRR, continuous thermodilution
Main finding
As reported in the abstract
Index of microcirculatory resistance (IMR)
0.95
Coronary flow reserve (CFR)
0.70
Microvascular resistance reserve (MRR)
0.59
Further findings
Mean
| Outcome | Continuous thermodilution | Bolus thermodilution | |
|---|---|---|---|
| FFR by continuous thermodilution vs standard FFR | 0.87 (SD 0.05) | Not reported in the abstract | bolus thermodilution: not reported in the abstract |
| CFR, continuous vs bolus thermodilution | 2.9 (SD 1.0) | 3.7 (SD 0.8) | |
| MRR, continuous vs bolus thermodilution | 3.4 (SD 1.1) | 4.8 (SD 1.3) |
- Fractional flow reserve (FFR) by continuous thermodilution vs standard FFR — Correlation R
- 0.89
- CFR, continuous vs bolus thermodilution — Correlation R
- 0.33
- MRR, continuous vs bolus thermodilution — Correlation R
- 0.34
- FFR by continuous thermodilution vs standard FFR: standard FFR mean 0.89 (SD 0.05)
- FFR by continuous thermodilution vs standard FFR: correlation P <0.001
- FFR by continuous thermodilution vs standard FFR: values significantly lower with continuous thermodilution, P =0.004
- CFR, continuous vs bolus thermodilution: correlation P =0.170
- CFR, continuous vs bolus thermodilution: values significantly lower with continuous thermodilution, P =0.003
- MRR, continuous vs bolus thermodilution: correlation P =0.155
- MRR, continuous vs bolus thermodilution: values significantly lower with continuous thermodilution, P <0.001
Repeatability (intraclass correlation coefficient): IMR vs CFR and MRR, bolus thermodilution
- IMR
- 0.95
- CFR
- 0.20
- MRR
- 0.33
- IMR vs CFR P <0.001
- IMR vs MRR P =0.002
Repeatability (intraclass correlation coefficient): IMR vs R Hyp
- IMR
- 0.95
- R Hyp
- 0.87
- P =0.188
Correlation of IMR and R Hyp
- Did not correlate, R
- 0.28
- P =0.226
Original publication
Summarised from the published abstract; every number is checked against it