Rescue of cardiac dysfunction during chemotherapy in acute myeloid leukaemia by blocking IL-1α
Authors' conclusion
This study revealed that crosstalk between tumour cells and cardiomyocytes during chemotherapy could disturb cardiac energy metabolism and impair heart function.
Study context
- Population
- Acute myeloid leukaemia (AML) patient after daunorubicin (DNR)-based chemotherapy; AML mice after DNR treatment
Main finding
As reported in the abstract
- In the AML patient, disrupted cardiac metabolic homeostasis associated with heart dysfunction after DNR-based chemotherapy
- In AML mice, attenuated cardiac fatty acid utilization with cardiac dysfunction after DNR; not seen in similarly treated tumour-free mice
- Tumour cell-derived IL-1α identified as a primary factor in DNR-induced cardiac dysfunction
- Anti-IL-1α neutralizing antibody could improve cardiac functions in AML mice after DNR
Original publication
Rescue of cardiac dysfunction during chemotherapy in acute myeloid leukaemia by blocking IL-1α. Eur Heart J. Published 12 April 2024. doi:10.
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