Patient characteristics, treatment patterns, and prognosis in drug-use-associated infective endocarditis in Denmark from 1999 to 2018
Authors' conclusion
In Denmark, the proportion of patients with DU-IE fell by one-third from 1999 to 2018. DU-IE was associated with higher mortality and recurrence rates than non-DU-IE.
Study context
- Population
- Patients with first-time infective endocarditis, Denmark, 1999–2018
- Participants
- 8,843 patients
- Exposure
- DU-IE vs non-DU-IE
- DU-IEn = 407
- non-DU-IEn = 8,436reference
- Outcome
- Temporal proportion of DU-IE; IE recurrence and mortality
Main finding
As reported in the abstract
Proportion of DU-IE · 1999 to 2018
- Proportion of DU-IE decreased from 5.9% to 3.8%
Observational data: associations, not effects.
Further findings
Cumulative incidence
| Outcome | DU-IE | non-DU-IE |
|---|---|---|
| All-cause mortality · 1 yearMultivariate Cox model | 16.9% (CI 12.9%–20.8%) | 17.3% (CI 16.4%–18.2%) |
| IE recurrence · 1 yearMultivariate cause-specific hazard model | 12.8% (CI 9.3%–16.3%) | 4.3% (CI 3.8%–4.8%) |
- All-cause mortality — Drug use associated with higher 1-year mortality, adjusted HR
- 1.64 (CI 1.23%-2.21%)
- IE recurrence — Drug use associated with higher 1-year IE recurrence, adjusted HR
- 3.39 (CI 2.35-4.88)
Original publication
Patient characteristics, treatment patterns, and prognosis in drug-use-associated infective endocarditis in Denmark from 1999 to 2018. Am Heart J. Published 12 April 2024. doi:10.
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