Heart failure & cardiomyopathies
Residual Pulmonary Hypertension and Clinical Outcomes in Acute Decompensated Heart Failure Patients Stratified By Left Ventricular Ejection Fraction
Authors' conclusion
The prognostic importance of residual PH was comparable across both HF with reduced and preserved ejection fraction patients.
Study context
- Population
- Hospitalised patients with acute decompensated heart failure (HF) (WET-HF registry)
- Participants
- 1,702 patients
- Exposure
- Residual pulmonary hypertension (PH) vs no PH, stratified by left ventricular ejection fraction (LVEF)
- nonPH-HF with LVEF <50%n = 689reference
- PH-HF with LVEF <50%n = 291
- nonPH-HF with LVEF ≥50%n = 453
- PH-HF with LVEF ≥50%n = 269
- Outcome
- Composite of:
- All-cause mortality
- HF rehospitalisation
- Follow-up
- 2 years
Methodological detailsmulticentre, registry (WET-HF)
- Multicentre
- Registry (WET-HF)
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
Outcomes by BNP improvement >30% vs less, nonPH-HF (subgroup)
Composite endpoint
All-cause mortality
HF rehospitalisation
- Outcomes by BNP improvement >30% vs less, nonPH-HF (subgroup): composite p < 0.001
- Outcomes by BNP improvement >30% vs less, nonPH-HF (subgroup): all-cause mortality p < 0.001
- Outcomes by BNP improvement >30% vs less, nonPH-HF (subgroup): HF rehospitalisation p = 0.001
Outcomes by BNP improvement, PH-HF (subgroup)
- No such difference evident
Original publication
Residual Pulmonary Hypertension and Clinical Outcomes in Acute Decompensated Heart Failure Patients Stratified By Left Ventricular Ejection Fraction. Eur J Heart Fail. Published 4 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →