Arrhythmias & electrophysiology
Respiratory control minimizes diaphragmatic contraction and dry cough during pulsed-field ablation of atrial fibrillation
Authors' conclusion
Pulsed-field ablation application at the end of expiration can reduce the severity of diaphragmatic contraction and eliminate moderate and severe dry cough during PV isolation performed under conscious sedation.
Study context
- Population
- Patients undergoing pulsed-field ablation (PFA) for pulmonary vein (PV) and superior vena cava isolation for AF under conscious sedation
- Participants
- 4,317 vs 1,401
- Exposure
- PFA at end of expiration vs PFA during any respiratory phase
- Testn = 4,317
- Controln = 1,401reference
- Outcome
- Diaphragmatic contraction and dry cough rating scores
Methodological detailswithin-patient comparison
- Within-patient comparison
Main finding
As reported in the abstract
| Group | Ablations with diaphragmatic contraction score ≧2 | Ablations with dry cough score ≧2 |
|---|---|---|
| Test | 0.4-2.6% | 0.7-2.1% |
| Control | 18.5-28.0% | 11.9-43.7% |
Ablations with diaphragmatic contraction score ≧2
Test0.4-2.6%
Control18.5-28.0%
Ablations with dry cough score ≧2
Test0.7-2.1%
Control11.9-43.7%
- Test vs Control: P < 0.01 — lower diaphragmatic contraction scores, all PVs
- Test vs Control: P < 0.001 — lower dry cough scores, all PVs
- Test vs Control: P < 0.001 — ablations with diaphragmatic contraction score ≧2
- Average relative reduction in diaphragmatic contraction scores, all PVs
- 33-47%
- Average relative reduction in dry cough scores, all PVs
- 67-83%
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Respiratory control minimizes diaphragmatic contraction and dry cough during pulsed-field ablation of atrial fibrillation. Europace. Published 2 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →