Respiratory stabilization before umbilical cord clamping in preterm neonates: a systematic review and network meta-analysis
Authors' conclusion
This NMA indicates that DCC, TBCC and PBCC probably have comparable effects on the important clinical outcomes in preterm neonates.
Study context
- Population
- Preterm neonates11 RCTs and 8 non-RCTs
- Comparison
- Cord clamping strategies with or without respiratory support before clamping in preterm neonates
- Outcome
- Mortality, severe IVH and MBI
Methodological detailsBayesian random effects, Medline, Embase and CENTRAL searched until April 2025
- Bayesian random effects
- Medline, Embase and CENTRAL searched until April 2025
Pooled result
As reported in the abstract
- Clinical benefit or harm could not be ruled out for mortality, severe IVH and MBI
Further pooled results
Mortality or neurodevelopmental impairment · 2 years' corrected age
- Deferred cord clamping (DCC)_ICR_more_60 vs immediate cord clamping (ICC) possibly decreased risk (low-certainty)
Original publication
Respiratory stabilization before umbilical cord clamping in preterm neonates: a systematic review and network meta-analysis. Resuscitation. Published 15 August 2025. doi:10.
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