Optimum oxygen concentration for initiation of delivery room stabilization in preterm neonates: A Randomized Controlled Trial
Primary resultResult — go to the resultRelative risk 1.53 95 % CI 1.18–1.97Authors' conclusion
A significantly higher number of preterm neonates < 34 weeks' gestation requiring DR stabilization achieved a 5-minute SpO2 of ≥ 80 % with higher minute-specific SpO2 trends when stabilized with an initial FiO2 of 60 % compared to 30 %.
Study context
- Population
- Preterm neonates < 34 weeks' gestation requiring respiratory support for delivery room stabilization
- Participants
- 150 neonates
- Comparison
- Initial fraction of inspired oxygen (FiO2) 60 % vs 30 % for delivery room (DR) stabilization
- 60 %n = 75
- 30 %n = 75reference
- Primary endpoint
- Proportion achieving target SpO2 ≥ 80 %
- Follow-up
- 5 min of life
Methodological detailsopen-label, assessor-blinded, parallel-group
- Open-label
- Assessor-blinded
- Parallel-group
Primary result
As reported in the abstract
Relative risk
1.53
95 % CI 1.18–1.97
P < 0.001
Events by treatment group
60 % vs 30 %
RR 1.53 (95 % CI 1.18–1.97); P < 0.001
Secondary outcomes
Minute-specific SpO2 and FiO2, HR trends · till 10 min
- Minute-specific SpO2 and FiO2 significantly higher with 60 %; HR trends comparable
CrSO2, respiratory support need and duration, surfactant, caffeine, hospital stay
- No difference
Original publication
Optimum oxygen concentration for initiation of delivery room stabilization in preterm neonates: A Randomized Controlled Trial. Resuscitation. Published 23 November 2024. doi:10.
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