Heart failure & cardiomyopathies
Rethinking Donor and Recipient Risk Matching in Europe and North America: Using Heart Transplant Predictors of Donor and Recipient Risk
Authors' conclusion
European heart transplantation centers are more likely to accept higher-risk donor hearts than North American centers.
Study context
- Population
- Heart transplant recipients in the ISHLT registry, Europe and North America, 2000–2018
- Exposure
- Donor-recipient risk matching; Europe vs North America
- Outcome
- Graft failure
- Follow-up
- 1 year
Methodological detailsISHLT registry, multivariable Cox regression
- ISHLT registry
- Multivariable Cox regression
Main finding
As reported in the abstract
1-year graft failure by donor/recipient risk group (North America)
- 1-year graft failure significantly associated with donor-recipient risk matching (log-rank)
- P < 0.001
Observational data: associations, not effects.
Further findings
Donor risk (Donor Utilization Score (DUS)), Europe vs North America
- European centres accept significantly higher-risk donor hearts than North America (DUS 0.45 vs 0.54)
- P < 0.005
DUS as independent predictor of graft failure
- DUS independent predictor of graft failure, inverse linear relationship, adjusted for covariates
- P < 0.001
IMPACT score (recipient risk) and 1-year graft failure
- IMPACT score independently associated with 1-year graft failure
- P < 0.001
Original publication
Rethinking Donor and Recipient Risk Matching in Europe and North America: Using Heart Transplant Predictors of Donor and Recipient Risk. Circ Heart Fail. Published 16 May 2023. doi:10.
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