Valvular & structural heart disease
The reversibility of cardiac damage after transcatheter aortic valve implantation and short-term outcomes in a real-world setting
Authors' conclusion
More than one-third of patients with severe AS showed an improvement in cardiac damage 6 months after TAVI. Staging cardiac damage at baseline and follow-up may improve risk stratification in patients undergoing TAVI.
Study context
- Population
- Patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI)patients with severe AS (mean age, 79.8 ± 7.4 years, 55% male)
- Participants
- 734 patients
- Exposure
- Changes in cardiac damage stage before and 6 months after TAVI
- Stage 0n = 32
- Stage 1n = 85
- Stage 2n = 220
- Stage 3n = 227
- Stage 4n = 170
- Outcome
- Cardiac damage stage before TAVI
- Follow-up
- Before TAVI
Methodological detailsreal-world cohort
- Real-world cohort
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| 2-year all-cause mortalityStaging of cardiac damage at 6 months after TAVI · independently associated · Multivariable Cox regression | HR per one-stage increase 1.391 | P = 0.035 |
| 2-year all-cause mortalityWorsening in the stage of cardiac damage · independently associated · Multivariable Cox regression | HR 3.729 | P = 0.005 |
Improvement of at least one stage in cardiac damage · Six months after TAVI
- Patients who improved at least one stage
- 39%
Original publication
The reversibility of cardiac damage after transcatheter aortic valve implantation and short-term outcomes in a real-world setting. Eur Heart J Cardiovasc Imaging. Published 4 February 2025. doi:10.
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