Heart failure & cardiomyopathies
Reversing the Cardiac Effects of Sedentary Aging in Middle Age—A Randomized Controlled Trial: Implications For Heart Failure Prevention
Authors' conclusion
In previously sedentary healthy middle-aged adults, 2 years of exercise training improved maximal oxygen uptake and decreased cardiac stiffness.
Study context
- Population
- Healthy, sedentary, middle-aged adults (53±5 years; 48% male)53 completed
- Participants
- 61 participants
- Comparison
- 2 years of supervised high-intensity exercise training vs attention control
- Exercise trainingn = 34
- Controln = 27reference
- Primary endpoint
- LV stiffness (stiffness constant from curve fit of the diastolic pressure-volume curve)
- Follow-up
- 2 years
Methodological detailsprospective, parallel group, Adherence to prescribed exercise sessions 88±11%
- Prospective
- Parallel group
- Adherence to prescribed exercise sessions 88±11%
Primary result
As reported in the abstract
LV stiffness constant · pre to post
| Group | Value | Pre | Pre vs post P |
|---|---|---|---|
| Exercise training | mean 0.051 (SD 0.0268) | 0.072±0.037 | P=0.0018 |
| Control | mean 0.062 (SD 0.031) | 0.0635±0.026 | P=0.83 |
Value
Exercise trainingmean 0.051 (SD 0.0268)
Controlmean 0.062 (SD 0.031)
Pre
Exercise training0.072±0.037
Control0.0635±0.026
Pre vs post P
Exercise trainingP=0.0018
ControlP=0.83
- Exercise training vs Control: P < 0.001 — right/downward shift in end-diastolic pressure-volume relationships
Further findings
| Outcome | Exercise training | Control | P value |
|---|---|---|---|
| Vo2max · pre to postVo2max increased by 18% with exercise · mean | 34.4 (SD 6.4) | 28.7 (SD 5.4) | P < 0.001 |
| Pre | 29.0±4.8 | 29.5±5.3 |
- Left ventricular (LV) end-diastolic volume · increased with exercise
- P < 0.001
- Pulmonary capillary wedge pressure and stroke volume · greater stroke volume for any given filling pressure
- P = 0.007
Pulmonary capillary wedge pressure and stroke volume
- Pulmonary capillary wedge pressure unchanged
Original publication
Reversing the Cardiac Effects of Sedentary Aging in Middle Age—A Randomized Controlled Trial: Implications For Heart Failure Prevention. Circulation. Published 8 January 2018. doi:10.
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