Heart failure & cardiomyopathies
Exercise Training and High-Sensitivity Cardiac Troponin-I in Patients with Heart Failure with Reduced Ejection Fraction
Authors' conclusion
In patients with stable HFrEF, 12 weeks of structured exercise intervention was associated with a modest, but significant reduction of hs-cTnI. There was no significant difference between intervention group and control group. In the sub-group of patients without additional co-morbidities, this difference was highly significant. The alterations in hs-cTnI were associated with reduction of LVEDD and natriuretic peptide concentrations as well as improved functional capacity.
Study context
- Population
- Patients with moderate chronic HF, NYHA class II–III, HFrEF
- Participants
- 196 patients
- Comparison
- Supervised exercise training vs recommendation of regular exercise
- High intensity interval training (HIIT)n = 70
- Moderate continuous training (MCT)n = 59
- Recommendation of regular exercise (RRE)n = 67reference
- Primary endpoint
- Change in serum hs-cTnI
- Follow-up
- 12 weeks
Primary result
As reported in the abstract
| Group | Baseline | 12 weeks | Within-group change |
|---|---|---|---|
| Supervised exercise training (SET) | 11.9 ng/L (IQR 7.1-21.8) | 11.5 ng/L (IQR 7.0-20.7) | P = 0.030 |
Supervised exercise training (SET)
- SET vs control group (CG): P = 0.116 — no between-group difference
- Numerical but not significant reduction in high sensitivity cardiac troponin I (hs-cTnI), whole population
- P = 0.067
Further findings
| Outcome | SET | P value |
|---|---|---|
| hs-cTnI change, patients without additional co-morbidities (subgroup) · 12 weeksSET vs CG · co-morbidities excluded: AF, hypertension, DM, COPD | delta −1.2 (IQR −2.7–0.1) ng/L | P = 0.007 |
| Change | 10.9 ng/L (IQR 6.0-22.7) to 9.2 ng/L (IQR 5.2-20.5), P = 0.002 |
- hs-cTnI change, patients without additional co-morbidities (subgroup): CG delta −0.1 (IQR −0.4–0.7) ng/L · Change 6.4 to 5.8 ng/L, P = 0.64
Association of hs-cTnI change with left ventricular end-diastolic diameter (LVEDD), VO2peak, N-terminal pro brain natriuretic peptide (NT-proBNP)
- Changes in hs-cTnI significantly associated with changes in LVEDD, VO2peak and NT-proBNP (all patients)
- Linear mixed models
Original publication
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