Pulmonary vascular disease & thromboembolism
Right Atrial Adaptation to Precapillary Pulmonary Hypertension: Pressure-Volume, Cardiomyocyte, and Histological Analysis
Authors' conclusion
RA PV loops show increased RA stiffness and suggest atrioventricular uncoupling in patients with severe RV diastolic stiffness. Isolated RA cardiomyocytes of precPH patients are hypertrophied, without intrinsic sarcomeric changes. In end-stage precPH, reduced capillary density is accompanied by interstitial and perivascular fibrosis.
Study context
- Population
- Patients with precapillary pulmonary hypertension and control subjects
- Participants
- 27 vs 9
- Comparison
- PrecPH vs control subjects
- PrecPHn = 27
- Controln = 9reference
- Outcome
- RA function (PV loops), RA stiffness and atrioventricular coupling, RA cardiomyocyte and histological changes in precPH
Main finding
As reported in the abstract
- Right atrial (RA) pressure-volume (PV) loops showed 3 RA cardiac phases (reservoir, passive emptying, contraction) with dilatation and elevated pressure in precapillary pulmonary hypertension (precPH)
- Severe vs moderate right ventricular (RV) diastolic stiffness: increased RA stiffness and worse right atrioventricular coupling index
- Cardiomyocyte cross-sectional area increased 2- to 3-fold in precPH; active sarcomeric tension unaltered
- No increase in passive tension of cardiomyocytes
- End-stage precPH: reduced capillaries per mm² with interstitial and perivascular fibrosis
Original publication
Right Atrial Adaptation to Precapillary Pulmonary Hypertension: Pressure-Volume, Cardiomyocyte, and Histological Analysis. J Am Coll Cardiol. Published 22 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →