Valvular & structural heart disease
Right Atrial-to-Right Ventricular Area: Prognostic Value in Patients With Secondary Tricuspid Regurgitation and Heart Failure
Authors' conclusion
Despite comparable quantified STR and neurohumoral activation, association between RA/RV ratio and mortality is robust.
Study context
- Population
- Patients with secondary tricuspid regurgitation (STR)1,219 severe STR
- Participants
- 13,174 patients
- Exposure
- Predominant atrial vs predominant ventricular remodeling (RA/RV area ratio) in secondary tricuspid regurgitation
- Outcome
- All-cause mortality
Main finding
As reported in the abstract
long-term
Each group vs at risk for severe STRHazard ratio (95% CI)P value
Predominant atrial remodeling
2.1(1.9–2.4)
P < 0.001Predominant ventricular remodeling
1.6(1.4–1.8)
P < 0.001Observational data: associations, not effects.
Further findings
| Outcome | Predominant atrial remodeling | Predominant ventricular remodeling | P value |
|---|---|---|---|
| Effective regurgitant orifice areaPredominant atrial remodeling vs Predominant ventricular remodeling | 0.45 | 0.46 | P > 0.904 |
| Vena contractaPredominant atrial remodeling vs Predominant ventricular remodeling | 13.7 | 13.5 | P = 0.322 |
| NT-proBNPPredominant atrial remodeling vs Predominant ventricular remodeling | 3,452 | 3,567 | P = 0.6 |
Original publication
Right Atrial-to-Right Ventricular Area: Prognostic Value in Patients With Secondary Tricuspid Regurgitation and Heart Failure. JACC Adv. Published 12 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →