Heart failure & cardiomyopathies
Right Ventricular Dysfunction and Adverse Clinical Outcomes in Peripartum Cardiomyopathy: A Meta-Analysis
Authors' conclusion
Our findings suggest that RV dysfunction at diagnosis is associated with a higher risk of major adverse outcomes and a lower likelihood of LV function recovery in PPCM.
Study context
- Population
- Patients with peripartum cardiomyopathy (PPCM) in studies with assessment of right ventricular (RV) function, major adverse outcomes, and LV systolic function recoveryFive studies, n = 117 with RV dysfunction, 1,212 person-years of follow-up
- Participants
- 472 patients
- Comparison
- RV dysfunction compared to those without RV dysfunction
- RV dysfunctionn = 117
- Outcome
- LV systolic function recovery (LV ejection fraction ≥50%) and major adverse clinical outcomes (LV assist device, recurrent heart failure hospitalization, orthotopic heart transplantation, or death)
Methodological detailsrandom-effect models
- Random-effect models
Pooled result
As reported in the abstract
RV dysfunction vs without RV dysfunctionOdds ratio (95% CI)P value
LV systolic function recovery; median follow-up 25 months (Q1-Q3: 6.8-36.9)
0.39(0.21–0.71)
P < 0.001Adverse clinical outcomes; median follow-up 32.9 months (Q1-Q3: 15.3-42.6)
4.19(2.23–7.85)
P < 0.001Further pooled results
- Mean age
- 32 ± 7 years
Original publication
Right Ventricular Dysfunction and Adverse Clinical Outcomes in Peripartum Cardiomyopathy: A Meta-Analysis. JACC Adv. Published 5 August 2025. doi:10.
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